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53rd ERA-EDTA Congress

 

21-24 May 2016 Vienna
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Discussion forum - 53rd ERA-EDTA Congress
    Topic - Chronic Kidney Disease. Anaemia.

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Poster: 327
Visits: 6
Title: THE ROLE OF PHOSPHORUS, PTH, FGF-23, KLOTHO AND VITAMIN D ON HEMOGLOBIN LEVELS OF PATIENTS WITH CKD
Authors: Luigi Russo , Yuri Battaglia , Dario Bruzzese , Biagio Di Iorio , Luca Di Lullo , Roberto Minutolo , Luigi Morrone
Centre: Dept Public Health. University FEDERICO II, Naples. Italy

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THE ROLE OF PHOSPHORUS, PTH, FGF-23, KLOTHO AND VITAMIN D ON HEMOGLOBIN LEVELS OF PATIENTS WITH CKD

Luigi Russo
Thread initiator
Subspeciality
Reg: 5/3/2016 3:08:00 PM
Comment# 1
Parathyroid hormone (PTH) is strong predictor of low levels of hemoglobin (Hb) in dialysis patients with severe hyperparathyroidism. Inverse association between PTH and Hb exists in non-dialysis CKD-patients and a doubled risk of Hb 10.0 mg/dL in absence of severely deranged PTH concentration. Higher phosphorus (P) levels associated with a greater likelihood for anemia both in early CKD-stages patientsand in subjects with normal kidney function suggesting that P may be a biomarkerof anemia. FGF-23 may play a role in the mechanisms leading to anemia through its interplay with serum P, vitamin D and suppression of Klotho. Low Klotho levels associated with senescence, cell toxicity, premature aging, vascular calcifications and deficiency in activated vitamin D. Vitamin D deficiency causes anemia.Aim of the study is to evaluate the role of P, PTH, FGF-23, Klotho and vitamin D on hemoglobin levels of patients with CKD not on dialysis. No previous study has assessed simultaneously these

Comment added on 5/3/2016 3:08:00 PM 
     
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